Proxy32 can create Separate Windows Desktop and start Proxy32 GUI on it. In this case programs started on Common Windows Desktop will be unable to interact with Proxy32 GUI (manipulate Proxy32 windows and send mouse and keyboard events into them). Running Proxy32 on the Separate Windows Desktop can be used for executing mission-critical tasks when user wants to avoid any interference from the other Windows applications.

Start on the Separate Windows Desktop is disabled by default but it can be enabled via Proxy32 Options Dialog.

When Proxy32 GUI is started on the Separate Windows Desktop, it allows user to switch back and forth between Separate and Common Windows Desktops: